Bubbles are always cool, and its also brought back memories of some brain storming sessions many years ago. Back then, we were running rather unconventional late night tests on material phase changes in the middle of an NMR pulse sequence. In other words, we reduced the dwell time between sequences in order to get to the donut shop before it closed. The net effect was that that the sample changed phase and was ruined…. thereby having to go bug the chem guys to make up some more compound, and do the run all over again.
Of course, since we already ruined the sample, we figured, hey, lets try some other things, as we’ve got 15 minutes. So then…. we hit on something cool. What was interesting was we were able to pinpoint target the location of the phase changes via tweaking the magnetic field gradient. We got so involved with this cool idea we forgot about the donut shop that night. Only now, 20 years later do I remember this.
What brought it to mind, is yet another paper I remember being presented at a conference somewhere, in that the authors were discussing ultrasound cavitaion as a function of envelope shape leading to the formation of free radicals. Since that time, I’ve always been a tad wary of ultrasound, although this arena has seen tremendous research over the years.
What would be an interesting experiment is to evalutate the ability of an NMR sequence to expand the bubbles. With the ability of much tighter focusing, and perhaps even position the bubbles location via thermal gradients, the combination of micro bubble expansion, and fMRI could lead to some rather interesting concepts.
Once an NMR guy, apparently always an NMR guy… just like the NMR temperature probe we designed on paper to capture the internal temperature of baked goods….